CURRENT DEVELOPMENTS IN THERAPEUTIC STRATEGIES FOR THE MANAGEMENT OF DIABETES: AN EXTENSIVE REVIEW

Abstract

Diabetes is a prime example of a rising global epidemic that is posing a severe social and economic threat to all nations. Notwithstanding advancements in science, enhanced healthcare infrastructure, and higher rates of literacy, the illness still affects many people, particularly in middle-class and lower-income nations. Current trends point to an increase in premature mortality, which is a serious threat to global development. Newer generation drugs such as sulfonylureas (K_ATP Channel Blockers), Biguanide (AMP_K activator), α - glucosidase inhibitors, with notable efficacy in lowering hyperglycemia have been developed as a result of scientific and technological advancements. Novel therapeutic classes such as incretin mimetics, amylin analogues, GIP analogs, peroxisome proliferator activated receptors, and dipeptidyl peptidase-4 inhibitors have been developed as a result of recent advances in drug discovery techniques. These compounds may find application in the treatment of diabetes.